Telomere biology and translational research
نویسندگان
چکیده
منابع مشابه
Telomere biology and cardiovascular disease.
Accumulation of cellular damage with advancing age leads to atherothrombosis and associated cardiovascular disease. Ageing is also characterized by shortening of the DNA component of telomeres, the specialized genetic segments located at the end of eukaryotic chromosomes that protect them from end-to-end fusions. By inducing genomic instability, replicative senescence and apoptosis, shortening ...
متن کاملTelomere biology in Metazoa.
In this review we present critical overview of some of the available literature on the fundamental biology of telomeres and telomerase in Metazoan. With the exception of Nematodes and Arthropods, the (TTAGGG)(n) sequence is conserved in most Metazoa. Available data show that telomerase-based end maintenance is a very ancient mechanism in unicellular and multicellular organisms. In invertebrates...
متن کاملTechniques in plant telomere biology.
The role model systems have played in understanding telomere biology has been enormous, and understanding has rapidly transferred to human telomere research. Most work using model organisms to study telomerase and nontelomerase-based telomere-maintenance systems has centered on yeasts, ciliates, and insects. But it is now timely to put considerably more effort into plant models for a number of ...
متن کاملTranslational Developmental Biology
Translational developmental biology is a growing approach to studying biological phenomena that explicitly aims to develop medical therapies. When discussing the generation of new therapies it is often argued that they will emerge as a ?translation? from ?fundamental biology.? Although translational research is not a new term, ?translational developmental biology? has been steadily gaining popu...
متن کاملTranslational Developmental Biology
Translational developmental biology is a growing approach to studying biological phenomena that explicitly aims to develop medical therapies. When discussing the generation of new therapies it is often argued that they will emerge as a ?translation? from ?fundamental biology.? Although translational research is not a new term, ?translational developmental biology? has been steadily gaining popu...
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ژورنال
عنوان ژورنال: Translational Research
سال: 2013
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2013.08.009